Publication details

Gonadoliberin (Gonadotropin-Releasing Hormone), Its Agonists and Antagonists

Authors

HOLICKÁ Martina VYSLOUŽIL Jakub KUBOVÁ Kateřina MUSELÍK Jan VETCHÝ David

Year of publication 2021
Type Article in Periodical
Magazine / Source CHEMICKÉ LISTY
MU Faculty or unit

Faculty of Pharmacy

Citation
Web http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3933/3844
Keywords GnRH analogues; GnRH agonist; GnRH antagonist; hormones; therapy
Description Nowadays, analogues of gonadotropin-releasing hormone are among the standard drugs in several indications, often using modern dosage forms. Globally, their market is estimated at billions of $ annually. This review article summarizes basic information on the relationship between structure and effect, pharmacology, and application of gonadotropin-releasing hormone and its synthetic analogues. Due to their properties, namely a higher efficiency and a higher binding affinity for the gonadotropinreleasing hormone receptor compared to native gonadotropin releasing hormone, the analogues have found applications in the treatment of many diseases, where it is necessary to suppress the secretion of gonadotropins and sex hormones. They are usually indicated for the treatment of cancers of various origins, premature puberty or artificial insemination. Due to their peptide nature, they are not administered orally, but require injection or intranasal administration. Compared to agonists, antagonists show faster onset of action and the absence of the so-called flareup phenomenon, i.e., temporarily increased serum levels of lutropin, follitropin and, consequently, of testosterone and estradiol.

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