Publication details
Mitogenomics of the endemic Ethiopian rats: looking for footprints of adaptive evolution in sky islands
| Authors | |
|---|---|
| Year of publication | 2021 |
| Type | Article in Periodical |
| Magazine / Source | Mitochondrion |
| MU Faculty or unit | |
| Citation | |
| Web | https://doi.org/10.1016/j.mito.2020.12.015 |
| Doi | http://dx.doi.org/10.1016/j.mito.2020.12.015 |
| Keywords | Adaptation; Adaptive introgression; Positive selection; dN; dS; Oxidative phosphorylation; NADH dehydrogenase |
| Description | Organisms living in high altitude must adapt to environmental conditions with hypoxia and low temperature, e. g. by changes in the structure and function of proteins associated with oxidative phosphorylation in mitochondria. Here we analysed the signs of adaptive evolution in 27 mitogenomes of endemic Ethiopian rats (Stenocephalemys), where individual species adapted to different elevation. Significant signals of positive selection were detected in 10 of the 13 mitochondrial protein-coding genes, with a majority of functional substitutions in the NADH dehydrogenase complex. Higher frequency of positively selected sites was found in phylogenetic lineages corresponding to Afroalpine specialists. |