Publication details

Application of two job indices for general occupational demands in a pooled analysis of case-control studies on lung cancer

Authors	HOVANEC J. SIEMIATYCKI J. CONWAY D. I. OLSSON A. GUENEL P. LUCE D. JOCKEL K. H. POHLABELN H. AHRENS W. KARRASCH S. WICHMANN H. E. GUSTAVSSON P. CONSONNI D. MERLETTI F. RICHIARDI L. SIMONATO L. FORTES C. PARENT M. E. MCLAUGHLIN J. R. DEMERS P. LANDI M. T. CAPORASO N. FERNANDEZ-TARDON G. ZARIDZE D. SWIATKOWSKA B. PANDICS T. LISSOWSKA J. FABIANOVA E. FIELD J. K. MATES D. BENCKO V. FORETOVÁ Lenka JANOUT V. KROMHOUT H. VERMEULEN R. BOFFETTA P. STRAIF K. SCHUZ J. CASJENS S. PESCH B. BRUNING T. BEHRENS T.
Year of publication	2021
Type	Article in Periodical
Magazine / Source	SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://www.sjweh.fi/show_abstract.php?abstract_id=3967
Doi	http://dx.doi.org/10.5271/sjweh.3967
Keywords	job index; psychosocial; smoking; social prestige; tumor subtype
Description	Objectives We investigated general job demands as a risk factor for lung cancer as well as their role in the association between occupational prestige and lung cancer. Methods In 13 case-control studies on lung cancer, as part of the international SYNERGY project, we applied indices for physical (PHI) and psychosocial (PSI) job demands - each with four categories (high to low). We estimated odds ratios (OR) and 95% confidence intervals (CI) for lung cancer by unconditional logistic regression, separately for men and women and adjusted for study centre, age, smoking behavior, and former employment in occupations with potential exposure to carcinogens. Further, we investigated, whether higher risks among men with low occupational prestige (Treiman's Standard International Occupational Prestige Scale) were affected by adjustment for the job indices. Results In 30 355 men and 7371 women, we found increased risks (OR) for lung cancer with high relative to low job demands in both men [PHI 1.74 (95% CI 1.56-1.93), PSI 1.33 (95% CI 1.17-1.51)] and women [PHI 1.62 (95% CI 1.24-2.11), PSI 1.31 (95% CI 1.09-1.56)]. OR for lung cancer among men with low occupational prestige were slightly reduced when adjusting for PHI [low versus high prestige OR from 1.44 (95% CI 1.32-1.58) to 1.30 (95% CI 1.17-1.45)], but not PSI. Conclusions Higher physical job demands were associated with increased risks of lung cancer, while associations for higher psychosocial demands were less strong. In contrast to physical demands, psychosocial demands did not contribute to clarify the association of occupational prestige and lung cancer.