Synthesis of C-prenylated analogues of stilbenoid methyl ethers and their cyclic dihydrobenzopyranyl derivatives as potential anti-inflammatory agents

• Authors: PÍŽOVÁ Hana; MALANÍK Milan; ŠMEJKAL Karel; ORAVEC Michal; BOBÁĽ Pavel
• Year of publication: 2022
• Type: Article in Periodical
• Magazine / Source: RSC Advances
• MU Faculty or unit: Faculty of Pharmacy
• Web: https://pubs.rsc.org/en/content/articlelanding/2022/RA/D2RA00441K
• Doi: http://dx.doi.org/10.1039/d2ra00441k
• Keywords: NATURAL STILBENOIDSVITIS-VINIFERAIN-VITRORESVERATROLDEMETHYLATIONINHIBITORSARYL
• Description: An efficient and versatile synthesis of the naturally occurring C-prenylated stilbenoid methyl ethers and their synthetic analogues is presented. The synthesis represents a six step convergent process including an optimised C-prenylation method. Furthermore, during the demethylation process, six new dihydro-benzopyranyl derivatives were obtained and isolated.

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