Publication details

Measurement of twitch contraction in isolated cardiac myocytes under the effect of various inotropic interventions

Authors

NOVÁKOVÁ Marie HASIN Yonathan

Year of publication 1994
Type Article in Proceedings
Conference Biosignal 94
MU Faculty or unit

Faculty of Medicine

Citation
Field Physiology
Keywords rat isolated cardiomyocytes;inotropic interventions
Description The amplitude of contraction and the restitution of contractility were compared under control conditions (1.2 mM extracellular Ca2+ concentration, 0.2 Hz stimulation rate), after partial Ca2+ channel blockade by Verapamil (in concentration 10-6M), at decreased Ca2+concentration in the medium (0.6 mM) and in the presence of beta-receptor inhibitor Metoprolol (in concentration 10-4 M). In all three situations the amplitude of contraction decreased to 60% of control and the mechanical restitution was proportionaly reduced in all its course. It seems that Metoprolol - even in absence of catecholamines - decreases intracellular Ca2+ concentration.

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