Publication details

Results of treatment of childhood chronic ITP



Year of publication 1998
Type Article in Periodical
Magazine / Source Scripta medica
MU Faculty or unit

Faculty of Medicine

Field Paediatry
Description Chronic childhood idiopathic (immune) thrombocytopenic purpura (ITP) is relatively rare, accounting only for 10-20% of children with ITP. Its treatment is very difficult. The therapeutic modalities are the following: steroids (high-dose or pulse therapy, high-dose immunoblobulin, interferon, anti-D immunoglobulin, cytotoxic immunosuppressives (azathioprine), splenectomy, etc. A group of 37 children with chronic ITP was treated during the last ten years in the First Department of Pediatrics. We used all above-mentioned curative options except of anti-D immunoglobulin. The permanent increase of the platelet count over 10x10/9/l as most often reached after splenectomy (11 children), cytotoxic immunosuppressives (4 children), steroids (2 children) and interferonu alpha 2a (2 children). The 2 children treated with interferon had even the permanent platelet count above 150x10/9/l. Regarding the undesireble side-effects of some therapy (splenectomy, storoids, cytotoxic immunosuppressives), we recomend to use interferon, which has minimal side-effects,a small group of patient can reach the permanent remission and the advantage is also the possibility to use interferon in outpatients.

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