Publication details
Effect of selected Indonesian plants on Giardia intestinalis in an experimental in vitro model
| Authors | |
|---|---|
| Year of publication | 2025 |
| Type | Article in Periodical |
| Magazine / Source | BMC COMPLEMENTARY MEDICINE AND THERAPIES |
| MU Faculty or unit | |
| Citation | |
| web | https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-025-04755-8 |
| Doi | http://dx.doi.org/10.1186/s12906-025-04755-8 |
| Keywords | Antigiardial activity; Drug of Choice; Giardia intestinalis; Natural Antiparasitic; Parasite |
| Description | This study evaluated in vitro antigiardial activity in four Indonesian plants (Archidendron fagifolium, Diospyros sumatrana, Piper betle and Shorea sumatrana) extracted in methanol, methanol-tetrahydrofuran, and water. These plants exhibiting promising anti-parasitic activity were selected on the basis of collected behavioral data and their ability to decrease parasite load in Sumatran orangutans. Extracts of Arabidopsis thaliana, a plant routinely used as a laboratory model in research, were used as a negative control. The results of our study show that extracts of A. fagifolium and P. betle have potential as an alternative treatment of G. intestinalis infection. This is the first scientific proof of the biological activity of A. fagifolium, confirming the assumption that orangutans use this plant (as well as P. betle) for self-medication. |
| Related projects: |