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Nano-savers for Ischemic stroke? Investigation using a combination of CT and LA-ICP-MS

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KUCHYNKA Michaela BISKUPIČ Jan PAROBKOVA Viktoria ZIKMUND Tomáš SCHEER Peter HLOŽKOVÁ Jana VLČNOVSKÁ Marcela KANICKÝ Viktor VACULOVIČ Tomáš KAISER Jozef

Year of publication 2024
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Pharmacy

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Description In the last decades, increased interest in imaging of elements/metals/proteins distribution of tissues, mainly in pharmaceutical, biomedicine research, or life science with direct application of research to specific problem/disease [1-3]. As WHO data indicates, cerebrovascular events are one of the main causes of mortality in developed nations. The key to success is time (as short as possible). Bio-degradable iodinated nanoparticles (IoNPs) could be an invaluable addition to the existing contrast agents used in medicine. A complete investiga-tion into the pharma-cokinetics and dynamics of IoNPs is essential to address this issue. With the combination of CT (computed tomography) and LA-ICP-MS imaging, this comprehensive evaluation verifies the treatment strategy's overall success, positioning LA-ICP-MS as a potential "gold standard" imaging method for researching and applying IoNPs in theranostics.
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