Publication details
Možné klinické vztahy mezi exokrinní a endokrinní pankreatickou funkcí
| Title in English | Possible clinical interactions beteween the exocrine and endocrine pankreas functions |
|---|---|
| Authors | |
| Year of publication | 2025 |
| Type | Peer-reviewed scientific article |
| Magazine / Source | Vnitřní lékařství |
| MU Faculty or unit | |
| Citation | |
| web | https://www.casopisvnitrnilekarstvi.cz/artkey/vnl-202502-0010_possible-clinical-interactions-beteween-the-exocrine-and-endocrine-pankreas-functions.php |
| Doi | https://doi.org/10.36290/vnl.2025.022 |
| Keywords | diabetes mellitus; pankreas physiology; interactions; chronic pancreatitis; pancreatic exokrine insufficiency; pancreatic endocrine insufficiency |
| Description | Pancreas is a vital organ fulfilling both exocrine and endocrine functions. The exocrine part is responsible for the production of digestive enzymes that are released into duodenum, while the endocrine part includes islets of Langerhans cells that produce hormones such as insulin, glucagon and somatostatin. Although these two parts are functionally distinct, there is a constant interaction between them. Disruption of this pathway can lead to a development of various diseases. Tumors or inflammation of the pancreas, trauma and surgery can lead to a secondary diabetes. If the insult simultaneously damages the acini and pancreatic islets, both exocrine and endocrine insufficiency will develop. Pancreatic exocrine insufficiency is very common in patients with diabetes, yet little is known about the association between these two units. The aim of this review article is to provide an overview of a pancreatic physiology, to summarize the pathophysiology and diagnostics of pancreatic exocrine insufficiency, and to focus on a possible relationships between exocrine pancreatic insufficiency and diabetes mellitus. |