Publication details
Biology and pharmacological inhibition of homeodomain-interacting protein kinases
| Authors | |
|---|---|
| Year of publication | 2025 |
| Type | Peer-reviewed scientific article |
| Magazine / Source | Frontiers in Chemical Biology |
| MU Faculty or unit | |
| Citation | |
| web | https://doi.org/10.3389/fchbi.2025.1441138 |
| Doi | https://doi.org/10.3389/fchbi.2025.1441138 |
| Keywords | HIPK; kinase; inhibitor; selectivity; neurology; cancer |
| Description | Homeodomain-interacting protein kinases (HIPKs) represent a relatively underexplored sub-family of serine/threonine protein kinases. However, the recently published studies point to the role of HIPKs in the developmental biology and etiology of pathological states, in particular cancer, and potential therapeutic applications of targeting this kinase family. This review summarizes the biology of HIPKs and their heretofore published small-molecule inhibitors. |
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