Publication details
Komentář k operativnímu postupu NIKEZ - Algoritmus diagnostiky maligní hypertermie v České republice, praktické konsekvence
| Title in English | Commentary on the standard operating procedure NIKEZ - Algorithm for the diagnosis of malignant hyperthermia in the Czech Republic and its practical consequences |
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| Authors | |
| Year of publication | 2025 |
| Type | Peer-reviewed scientific article |
| Magazine / Source | Anesteziologie a intenzivní medicína |
| MU Faculty or unit | |
| Citation | |
| web | https://www.aimjournal.cz/en/artkey/aim-202502-0011_commentary-on-the-standard-operating-procedure-nikez-algorithm-for-the-diagnosis-of-malignant-hyperthermia-in-t.php?back=%2Fsearch.php?query%3D%255B%2BSite%253A%2BSig8.com%2B%255D%252Cpaypal%2Blimitatio |
| Doi | https://doi.org/10.36290/aim.2025.018 |
| Keywords | malignant hyperthermia; diagnostic algorithm; NIKEZ; standard operating procedure; Czech Republic |
| Attached files | |
| Description | Malignant hyperthermia (MH) is generally defined as a serious pharmacogenetic disorder. In susceptible individuals, in the presence of triggers (volatile anesthetics and the depolarizing muscle relaxant succinylcholine), a severe hypermetabolic reaction develops due to a disturbance in calcium transport in skeletal muscle cells, leading to multi-organ failure and death. MH reactions are typically accompanied by generalized muscle rigidity and hyperpyrexia. For many years, the prevailing view of malignant hyperthermia was that it was an exceptionally rare, completely unpredictable, extremely severe, life-threatening complication of general anesthesia. Every anesthesiologist hoped and believed that they would encounter it at most once in their professional career (and would remember it forever), or, in the best-case scenario, never encounter MH at all. The only way to diagnose MH was to perform an invasive and technically demanding muscle test on the patient in a specialized laboratory (in vitro contraction test (IVCT)), and this was only possible in the most advanced countries in the world. In the Czech Republic (CR), the first IVCT was successfully performed in 2002. |
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