Publication details
Optimalizace koncentrace EDTA v kombinaci s chitosanem a antimikrobiálními peptidy pro léčbu ran
| Title in English | Optimization of EDTA concentration in combination with chitosan and antimicrobial peptides for wound treatment |
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| Authors | |
| Year of publication | 2025 |
| Type | Appeared in Conference without Proceedings |
| MU Faculty or unit | |
| Citation | |
| Description | The treatment of skin and soft tissue infections, particularly those complicated by biofilm formation and drug-resistant microorganisms, is a growing problem in modern healthcare. The use of combination therapies utilizing chelating agents such as ethylenediaminetetraacetic acid (EDTA), biopolymers such as chitosan, and antimicrobial peptides (AMPs) appears to be a promising strategy for enhancing antimicrobial efficacy and promoting tissue regeneration. A key aspect of this combined approach is the identification of EDTA concentrations that provide maximum antimicrobial effects while maintaining compatibility, low cytotoxicity, and formulation stability for topical wound applications. A carbapenemase-resistant strain of Pseudomonas aeruginosa was used to determine the ideal antimicrobial composition. A synergistic effect of EDTA with both chitosan and antimicrobial peptides was demonstrated at concentrations that are commonly considered non-toxic to the human body. |
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