Response to Letter to Editor by A. Derbalah et al.: the role of automation in enhancing reproducibility and interoperability of PBPK models

• Authors: DOMINGUEZ ROMERO Elena; MAZURENKO Stanislav; SCHERINGER Martin; DOS SANTOS Vitor A. P. Martins; EVELO Chris T.; ANTON Mihail; HANCOCK John M.; ZUPANIC Anze; SUAREZ-DIEZ Maria
• Year of publication: 2025
• Type: Article in Periodical
• Magazine / Source: BRIEFINGS IN BIOINFORMATICS
• MU Faculty or unit: Faculty of Science
• web: https://academic.oup.com/bib/article/26/1/bbaf060/8006249
• Doi: https://doi.org/10.1093/bib/bbaf060
• Keywords: reproducibility; PBPK models; standardization; automation
• Description: This text discusses automation in physiologically based pharmacokinetic (PBPK) modeling, emphasizing its benefits for building complex models efficiently and reproducibly. Manual scripting remains valuable for smaller models for teaching and conceptual understanding. The authors highlight the need for standardization and open collaboration through ELIXIR to advance automated PBPK model development.