Publication details
Multiscale Analysis of Biological Systems: Integrating Imaging, Mechanical Characterization, and Chemical Profiling
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| Year of publication | 2025 |
| Type | Conference abstract |
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| Description | Scientific Core Facilities are pivotal within research institutions, providing access to advanced technologies, equipment, and expertise. They empower researchers and students through training, technical support, education, and consultation. Our facility specializes in atomic force microscopy (AFM) applied to biological samples, combined with advanced correlative microscopy techniques such as optical and Raman microscopy, uniquely complementing more established methods. By fostering interdisciplinary collaborations and emphasizing meticulous experimental planning, we have successfully applied force microscopy in diverse modes to achieve significant results in bio-related projects. Notable applications include imaging single molecules to elucidate their structure and interactions, exploring the mechanical properties of microenvironments on cellular behavior [2], assessing the effects of nanoparticles on cell growth and function, and investigating pathological phenomena such as liver fibrosis formation and treatment. These studies have provided valuable insights into molecular mechanisms and cellular dynamics. Our facility also integrates correlative approaches to combine complementary data from different modalities. For instance, hybrid techniques like AFM coupled with optical or Raman microscopy allow simultaneous acquisition of mechanical, structural, and chemical information. This multimodal strategy enhances our ability to analyze complex biological systems at multiple scales. |
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