Publication details
Onion Thiolanes: Multifunctional Modulators of Oxidative Stress, PPAR-γ2 Signaling, and Bacterial Growth
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| Year of publication | 2025 |
| Type | Appeared in Conference without Proceedings |
| Citation | |
| Description | This study evaluates the biological activity of thiolane derivatives isolated from onion (Allium cepa L.). Twenty-four sulfur-containing compounds were tested for their effects on oxidative stress, NF-?B signaling, PPAR-?2 activation, and antimicrobial activity. Most thiolanes did not significantly inhibit LPS-induced NF-?B activation, suggesting limited anti-inflammatory activity via this pathway. In contrast, several compounds reduced reactive oxygen species under oxidative stress conditions and moderately activated the PPAR-?2 pathway, indicating potential effects on metabolic regulation. Antimicrobial testing showed selective activity against Staphylococcus aureus, while no inhibitory effects were observed against Escherichia coli or Candida albicans. Overall, onion-derived thiolanes demonstrated moderate antioxidant and metabolic modulatory properties with selective antibacterial effects. Further studies are required to clarify their mechanisms of action and potential applications. |