Publication details
Structure activity relationship of flavonoids as PPARγ agonists
| Authors | |
|---|---|
| Year of publication | 2025 |
| Type | Article in Periodical |
| Magazine / Source | Phytochemistry reviews |
| MU Faculty or unit | |
| Citation | |
| web | https://link.springer.com/article/10.1007/s11101-025-10121-w?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate |
| Doi | https://doi.org/10.1007/s11101-025-10121-w |
| Keywords | Flavonoids; Isoflavones; Diabetes mellitus; PPAR gamma |
| Description | Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a transcriptional factor and key regulatory element in glucose and lipid metabolism. We have attempted to determine the structure-activity relationship between flavonoids as PPAR gamma agonists through a literature search. To compare results from different studies and methods, we have recalculated them to the percentage of positive control (%PC). We have also described various methods used to determine PPAR gamma agonists. The most promising PPAR gamma agonists are isoflavones, namely 4'-fluoro-7-hydroxyisoflavone (4; %PC = 710.3%). The results presented in this review could be used for further semisynthetic modifications of flavonoids to enhance their PPAR gamma agonistic activity. |