Publication details
Rapid Determination of Nimesulide by Capillary Zone Electrophoresis in Various Pharmaceutical Formulations
| Authors | |
|---|---|
| Year of publication | 2025 |
| Type | Peer-reviewed scientific article |
| Magazine / Source | SEPARATIONS |
| MU Faculty or unit | |
| Citation | |
| web | https://www.mdpi.com/2297-8739/12/5/132 |
| Doi | https://doi.org/10.3390/separations12050132 |
| Keywords | CZE; gel; nimesulide; NSAID; rapid determination; tablets; sachets |
| Description | Nimesulide is a popular non-steroidal anti-inflammatory drug (NSAID) and a cyclooxygenase-2 inhibitor available in more than 50 countries worldwide. A rapid and simple method for nimesulide determination is presented. Experimental parameters based on a previously published work were revised and adopted into a method with significantly better performance: pH was shifted from 8.10 to 9.25, borate background electrolyte concentration from 10 to 60 mM-resulting in a run time less than 4 min, and number of theoretical plates greater than 100,000. The method was validated and applied for the determination of nimesulide in three formulations with the active substance of nimesulide: tablets, gel, and powder (in sachets for oral suspension). Also, the tablets were tested for uniformity of content of single-dose preparations according to Ph. Eur. |