Publication details
A comprehensive system of algorithms for characterization of cardiomyocyte mechanical and electrical function
| Authors | |
|---|---|
| Year of publication | 2026 |
| Type | Article in Periodical |
| Magazine / Source | Biomedical Signal Processing and Control |
| MU Faculty or unit | |
| Citation | |
| web | https://www.sciencedirect.com/science/article/pii/S1746809426006798?getft_integrator=clarivate&pes=vor&utm_source=clarivate |
| Doi | https://doi.org/10.1016/j.bspc.2026.110125 |
| Keywords | Biomechanics; Cardiomyocytes; Biometrics; Atomic Force Microscopy; Multielectrode Array; Electromechanical Decoupling |
| Attached files | |
| Description | Understanding the mechanical and electrical function of cardiomyocytes is crucial to unraveling the intricate mechanisms of cardiac physiology and provides insights into the basis of cardiac function and dysfunction. The link between these two aspects provides a holistic perspective and essential knowledge for advancing cardiac research, diagnostics, and therapeutic interventions to combat cardiovascular disease, a leading cause of morbidity and mortality worldwide. A set of Python-based scripts for analyzing mechanical and electrical signals from cardiac cells acquired using Atomic Force Microscopy (AFM) and Multi-Electrode Array (MEA) techniques is presented. The integration of AFM and MEA allows the simultaneous probing of cellular mechanics and electrophysiology. The scripts offer a novel, systematic framework for importing, processing, and interpreting data from complex AFM-MEA experimental setups. Mechanocardiograms obtained from AFM vertical deflection and electrical signals obtained from MEA recordings can be analyzed. The scripts include advanced algorithms for quantifying key parameters, such as beat rate, arrhythmia classification, contraction force, and field potential properties. Additionally, the presented methodology facilitates the correlation between mechanical and electrical behavior. These scripts provide a valuable toolkit for researchers conducting cardiac physiology studies, offering a standardized, efficient approach to unraveling the intricacies of cardiomyocyte behavior in vitro. |
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