Brain Alterations Linked to the MPTP Mouse Model of Parkinson's Disease Uncovered by Diffusion Kurtosis Imaging and Magnetic Resonance Spectroscopy

• Authors: MODI Ajay; MARIA Sheetal; RUDÁ Jana; DRAŽANOVÁ Eva; HARAŠTOVÁ Iveta; ŠEJNOHA MINSTEROVÁ Alžběta; KOVAČOVICOVÁ Kristína; HAVAS Daniel; REKTOROVÁ Irena; OUTEIRO Tiago F.; KHAIRNAR Amit Suresh
• Year of publication: 2026
• Type: Peer-reviewed scientific article
• Magazine / Source: CNS Neuroscience & Therapeutics
• MU Faculty or unit: Faculty of Medicine
• web: https://onlinelibrary.wiley.com/doi/epdf/10.1002/cns.70846
• Doi: https://doi.org/10.1002/cns.70846
• Keywords: Parkinson’s disease; MPTP animal model; Neurodegeneration; Diffusion Kurtosis Imaging (DKI); Proton Magnetic Resonance Spectroscopy (1H-MRS); Microstructural changes
• Description: These findings demonstrate DKI and 1H-MRS are sensitive, non-invasive modalities for detecting and monitoring neurodegenerative microstructural and neurochemical changes, enhancing the understanding of PD-related pathology and progression.

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