Publication details

Genetic variations in the matrix metalloproteinase-1 (MMP-1) promoter and risk of susceptibility and/or severity of chronic periodontitis in the Czech population

Authors

IZAKOVIČOVÁ HOLLÁ Lydie JURAJDA Michal FASSMANN Antonín DVOŘÁKOVÁ Naděžda ZNOJIL Vladimír VÁCHA Jiří

Year of publication 2004
Type Article in Periodical
Magazine / Source J Clin Periodontol
MU Faculty or unit

Faculty of Medicine

Citation
Field Genetics and molecular biology
Keywords periodontitis; MMP-1; matrix metalloproteinase; haplotype; gene
Description Matrix metalloproteinase-1 (MMP-1) is a potent enzyme degrading extracellular matrix, which was implicated in the pathogenesis of chronic periodontitis. Therefore, the aim of our study was to examine the association between three promoter polymorphisms of the MMP-1 gene and chronic periodontitis susceptibility and/or severity in a Czech population.
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