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Příjem, biologická dostupnost a metabolismus rostlinných polyfenolů u člověka

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Title in English Intake, Bioavailability, and Metabolisms of Plant Polyphenols in Humans


Year of publication 2004
Type Article in Periodical
Magazine / Source Chemické listy
MU Faculty or unit

Faculty of Medicine

Field Biochemistry
Keywords bioavailability; polyphenols; flavonoids; phenolic acids; quercetin; chlorogenic acid; antioxidants
Description The total intake of plant polyphenols is about 1 g/day, major part accounts for flavonoids and phenolic acids. The main polyphenol dietary sources are beverages (tea, coffee, wine, fruit juice) and fruits. Large uncertainness are regarding of the intake of several classes of plant polyphenols, such as oligomeric proanthocyanidins and phenolic acids. The intestinal absorption of polyphenols is probably high, but the plasma concentration of parent polyphenol is low. The majority of polyphenols is subject to hydrolysis in digestive tract and is metabolized by the colonic microflora largely to phenolic acids, which can be also absorbed. After absorption, polyphenols and their metabolites are further conjugated in tissue. These transformations let to high number of metabolites, many of them retain the antioxidant activity.
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