Publication details

Improved 3D Reconstruction of Interphase Chromosomes Based on Nonlinear Diffusion Filtering

Authors

HUBENÝ Jan MATULA Pavel MATULA Petr KOZUBEK Michal

Year of publication 2006
Type Article in Proceedings
Conference Proceedings of PDE-Based Image Processing and Related Inverse Problems
MU Faculty or unit

Faculty of Informatics

Citation
Field Informatics
Keywords Nonlinear diffusion filtering; PDE based image processing; interphase chromosomes; biomedical application
Description A recently published method for 3D reconstruction of interphase chromosomes based on the fast marching method was extended. A kind of anisotropic diffusion filtering, namely the balanced forward-backward diffusion filtering, was added to the preprocessing phase of the algorithm. The method for finding an optimal arrival time was also modified. The anisotropic diffusion filtering can suppress inhomogeneities in chromosome staining while edges in images are preserved. This leads to better performance for chromosomes that are close to each other.
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