Publication details

Role genetické variability vybraných antioxidačních enzymů u diabetické nefropatie - pilotní výsledky

Title in English The role of genetic variability in candidate antioxidant enzymes in diabetic nephropathy - a pilot study


Year of publication 2006
Type Article in Periodical
Magazine / Source Diabetologie Metabolismus Endokrinologie Výživa
MU Faculty or unit

Faculty of Medicine

Field Endocrinology, diabetology, metabolism, nutrition
Keywords diabetes; nephropathy; susceptibility; polymorphism
Description Diabetic nephropathy (DN) develops as a result of hemodynamic and metabolic changes accompanying diabetes. Hyperglycemia-induced overproduction of reactive oxygen species (ROS) is an important pathogenic determinant of DN. (In)efficient cellular protection by antioxidant enzymes is reflected in the overall extent of oxidative damage. Genetic variability in genes encoding antioxidant enzymes belong to functional candidates potentially modulating susceptibility to DN. Subsequently, oxidative DNA damage due to ROS overproduction activates DNA reparation. Unfortunately, this further aggravates cellular dysfunction/damage due to consumption of energy substrates and metabolic cofactors. The aim of the study was to investigate relationship between genetic variability in genes encoding poly-(ADP-ribose) polymerase (ADPRT), manganese superoxide dismutase (SOD2), catalase (CAT), glutathion peroxidase (GPx) and susceptibility to DN.
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