Publication details
Activity-dependent changes of [Ca2+] in the transverse-axial tubular system reduce SR Ca2+ content and Ca2+ transient amplitude in rat and guinea pig cardiac ventricular myocytes: a simulation study
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| Year of publication | 2006 |
| Type | Conference abstract |
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| Description | To explore the physiological consequences of ion concentration changes in the transverse-axial tubular system (TATS) of rat and guinea-pig cardiac ventricular myocytes, we have developed mathematical models of their electrical activity that include a quantitative description of the TATS. In both models, transient depletion of tubular Ca2+ occurred during each action potential and decreased intracellular Ca2+ load and consequently systolic Ca2+ transient amplitude. However, the magnitude of this effect and its frequency dependence was different in the two species. |
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