Publication details

The Effect of Head Injury Upon the Immune System

Authors

SMRČKA Martin MRLIAN Andrej KARLSSON-VALIK John KLABUSAY Martin

Type Article in Periodical
Magazine / Source Bratislavské Lekárské Listy
MU Faculty or unit

Faculty of Medicine

Citation
Field Neurology, neurosurgery, neurosciences
Keywords severe head injuries; immune system; stress reaction; TH2 dominance
Description Severe head injurier are characterized by high mortality and morbidity. In spite of guidelines based therapy the treatment is frequently unsuccessful. Extracranial infectious complications are considered to be an important problem during the course of recovery, and possibly immunological changes could explain their occurrence. Finally, TH2 dominance induces IgE levels accumulation. All these changes are strongly under effect of stress based release of endogenous glucocorticoids and catecholamine, which influence the complex network of cytokines and cell mediators.
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