Publication details
Ultrasonic Shock-Wave as a Control Mechanism for Liposome Drug Delivery System for Possible Use in Scaffold Implanted to Animals with Iatrogenic Articular Cartilage Defects
| Authors | |
|---|---|
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | Acta Veterinaria |
| MU Faculty or unit | |
| Citation | |
| Field | Traumatology and orthopaedic surgery |
| Keywords | Liposome;controlled drug delivery;ultrasound shock-wave;fluorescence |
| Description | A short liposome exposure to ultrasonic waves with the intensity of I = 2 W/cm2 at frequency f = 1 MHz was found to be a sufficient tool for liposome opening. In addition, shock-wave proved to be sufficient also for liposome content release. Both methods are useful tools to be used as control mechanisms for drug delivery systems based on liposomes. However, due to better focusing and low non-thermal side effects, shock-waves probably have a markedly higher potential for successful use. |