Publication details

Ultrasonic Shock-Wave as a Control Mechanism for Liposome Drug Delivery System for Possible Use in Scaffold Implanted to Animals with Iatrogenic Articular Cartilage Defects

Authors

MICKOVÁ A. TOMÁNKOVÁ K. KOLÁŘOVÁ H. BAJGAR R. KOLÁŘ P. ŠUNKA Pavel PLENCNER P. JAKUBOVÁ M. BENEŠ J. KOLÁČNÁ L. PLÁNKA Ladislav NEČAS Alois AMLER E.

Year of publication 2008
Type Article in Periodical
Magazine / Source Acta Veterinaria
MU Faculty or unit

Faculty of Medicine

Citation
Field Traumatology and orthopaedic surgery
Keywords Liposome;controlled drug delivery;ultrasound shock-wave;fluorescence
Description A short liposome exposure to ultrasonic waves with the intensity of I = 2 W/cm2 at frequency f = 1 MHz was found to be a sufficient tool for liposome opening. In addition, shock-wave proved to be sufficient also for liposome content release. Both methods are useful tools to be used as control mechanisms for drug delivery systems based on liposomes. However, due to better focusing and low non-thermal side effects, shock-waves probably have a markedly higher potential for successful use.