Publication details
Kožní nežádoucí účinky amiodaronu
| Title in English | Skin adverse effects of amiodarone |
|---|---|
| Authors | |
| Year of publication | 2008 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Amiodarone has belonged to frequently used antiarrhythmic in the treatment of supraventricular and ventricular tachyarrhytmias since the sixthies. Amiodarone is a chemically iodinated benzofuran derivative with mono-N-desethylamiodarone as its major metabolite. Its use associated with numerous adverse reactions. The incidence of amiodarone induced side-effects ranges from 16-98 % of patients receiving amiodarone and it appears to be dose related. Skin side-effects are common, they usually occur as photosensitivity, more rarely as a slategrey discoloration of the skin. Leucocytoclastic vasculitis, allergic-type reaction, hair loss and exacerbation of psoriasis have also been infrequently reported. Amiodarone induced slate-gray pigmentation is commonly observed in unprotected light exposed skin. Its incidence ranges from 2-57 %. Hyperpigmentations is due to accumulation of amiodarone and its metabolite in the skin. We describe three cases of hyperpigmentation after using amiodarone in elder men. |