Publication details

Carvedilol and adrenergic agonists supress the lipopolysaccharide-induced NO production in RAW 264.7 macrophages via the adrenergic receptors

Authors

PEKAROVÁ Michaela MORAVCOVÁ Jana KUBALA Lukáš ČÍŽ Milan PAPEŽÍKOVÁ Ivana MACICKOVÁ Tatiana PECIVOVA Jana NOSÁL Radomír LOJEK Antonín

Year of publication 2009
Type Article in Periodical
Magazine / Source Journal Physiology and Pharmacology
MU Faculty or unit

Faculty of Science

Citation
Field Physiology
Keywords carvedilol adrenergic agonists adrenergic antagonists macrophages nitric oxide
Description In this study, the effect of carvedilol on LPS-treated RAW 264.7 cells was investigated. It was demonstrated that carvedilol inhibits LPS-induced NO production and iNOS protein expression in macrophages and that these effects are mediated, at least in part, by the interaction of carvedilol with adrenergic receptors.

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