Pacientka s AL- amyloidózou a závažným deficitem faktoru X je po vysokodávkované chemoterapii již 7 let v kompletní hematologické remisi s normální aktivitou faktoru X. Popis případu a přehled literatury

• Title in English: A patient with AL amyloidosis and severe factor X deficiency has been in complete haematological remission with normal factor X activity for 7 years following high-dose chemotherapy. A case study and literature review
• Authors: ADAM Zdeněk; MATÝŠKOVÁ M.; KREJČÍ Marta; POUR Luděk; KISSOVÁ J.; ŠLECHTOVÁ M.; CHLUPOVÁ G.; STAVAŘOVÁ Yveta; SIMONIDES Jan; PENKA Miroslav; MAYER Jiří; HÁJEK Roman
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: Vnitřní lékařství
• MU Faculty or unit: Faculty of Medicine
• Field: Oncology and hematology
• Keywords: factor X - AL amyloidosis;multiple myeloma;monoclonal gammopathy;high-dose chemotherapy
• Description: In this paper are described a frequent complications of AL amyloidosis: disturbance of haemostasis and bleeding. These are frequently caused by increased fragility of capillaries, thrombocyte function disorders and coagulation cascade defects.

Related projects

• University Research Centre - Czech Myeloma Group
• From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies