Publication details

Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models

Authors

ŠMEJKAL Karel ŠLAPETOVÁ Tereza KRMENČÍK Pavel KUBÍNOVÁ Renata SUCHÝ Pavel DALLACQUA Stefano INNOCENTI Gabbriella VANČO Ján KALVAROVÁ Karolína DVORSKÁ Margita SLANINA Jiří KRAMÁŘOVÁ Eva MUSELÍK Jan ŽEMLIČKA Milan

Year of publication 2010
Type Article in Periodical
Magazine / Source Molecules
MU Faculty or unit

Faculty of Medicine

Citation
Field Organic chemistry
Keywords Schisandra chinensis; dibenzocyclooctadiene lignans; antiradical; diabetes mellitus
Description The in vitro antiradical activity of Schisandra chinensis lignans was investigated using DPPH, ABTS, Fenton reaction inhibition and tyrosine-nitration inhibition assays, as were the in vivo antidiabetic activities of selected lignans in an animal model of alloxaninduced diabetes. Different degrees of antiradical activity were found, depending upon the structural parameters of the tested compounds. Unfortunately, the compounds showed no antidiabetic activity in concentration range tested.
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