Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models

• Authors: ŠMEJKAL Karel; ŠLAPETOVÁ Tereza; KRMENČÍK Pavel; KUBÍNOVÁ Renata; SUCHÝ Pavel; DALLACQUA Stefano; INNOCENTI Gabbriella; VANČO Ján; KALVAROVÁ Karolína; DVORSKÁ Margita; SLANINA Jiří; KRAMÁŘOVÁ Eva; MUSELÍK Jan; ŽEMLIČKA Milan
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: Molecules
• MU Faculty or unit: Faculty of Medicine
• Field: Organic chemistry
• Keywords: Schisandra chinensis; dibenzocyclooctadiene lignans; antiradical; diabetes mellitus
• Description: The in vitro antiradical activity of Schisandra chinensis lignans was investigated using DPPH, ABTS, Fenton reaction inhibition and tyrosine-nitration inhibition assays, as were the in vivo antidiabetic activities of selected lignans in an animal model of alloxaninduced diabetes. Different degrees of antiradical activity were found, depending upon the structural parameters of the tested compounds. Unfortunately, the compounds showed no antidiabetic activity in concentration range tested.

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