Publication details
Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Journal of experimental & clinical cancer research |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.jeccr.com/content/pdf/1756-9966-29-90.pdf |
| Doi | http://dx.doi.org/10.1186/1756-9966-29-90 |
| Field | Oncology and hematology |
| Keywords | MicroRNA; renal cell carcinoma; miRNA-106b; nephrectomy |
| Description | MicroRNAs are endogenously expressed regulatory noncoding RNAs. We examined the expression levels of selected microRNAs in 38 samples of conventional renal cell carcinoma (RCC) and 10 samples of non-tumoral renal parenchyma using TaqMan real-time PCR method. We have confirmed previous observations obtained by miRNA microarray analysis using standardized real-time PCR method. For the first time, we have identified a prognostic significance of miRNA-106b, which, after validation on a larger group of patients, maybe useful as a promising biomarker in patients with RCC. |