Publication details

Léčba osteochondrálních defektů kolenního kloubu metodou implantace solidního chondrograftu - dlouhodobé výsledky

Title in English Treatment of deep cartilage defects of the knee with autologous chondrocyte transplantatin: long-term results


Year of publication 2010
Type Article in Periodical
Magazine / Source Acta Chirurgiae orthopaedicae et Traumatologiae čechoslovaca
MU Faculty or unit

Faculty of Medicine

Field Traumatology and orthopaedic surgery
Keywords knee joint; chondrocytes; autologous cartilage transplantation
Description Indication for autologous chondrocyte transplantation most frequently included trauma to the knee - chondral lesions categorized as grades III a and III b by Noyes-Stabler classification. A small sample of cartilage was harvested arthroscopically and after 4-5 weeks the cultured chondrocytes formed into a solid chondral graft were implanted at the damage site of the medial or lateral femoral condyle and fixed with fibrin glue. 52 patients - 34 males, average age 29 years - were treated by autologous chondrocyte transplantation in the period from 2001 to 2009. Average follow-up was 46 months. 13 patients were examined by MRI - average 19 months - after the implantation and full incorporation the chondrograft was observed in 92.3% of cases. The clinical results evaluated by Lysholm scoring system showed significant improvement. In 24 patients imunohistochemical examination in samples taken by second look arthroscopy from the borders of implantation detected hyaline chondral tissue and collagen type II in all samples.

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