Publication details
Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Acta Physiologica |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1111/j.1748-1716.2010.02162.x |
| Field | Physiology |
| Keywords | ethanol; action potential; sodium current; calcium current; transient outward potassium current; rat ventricular myocytes |
| Description | Ethanol reversibly decelerated the upstroke velocity and decreased AP amplitude and duration at 0.2 and 3 Hz. The fast sodium current INa, L-type calcium current ICa and transient outward potassium current Ito were reversibly inhibited in a concentration-dependent manner.As a consequence of marked differences in nH, sensitivity of the currents to ethanol at 10%-inhibition decreases in the following order: ICa (75 mM, 3.5 promile), Ito (170 mM, 7.8 promile) and INa (220 mM, 10.1 promile). |
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