Publication details

IDH2 mutations in patients with acute myeloid leukemia: missense p.R140 mutations are linked to disease status

Authors

JEŽÍŠKOVÁ Ivana RÁZGA Filip BAJEROVÁ Monika RÁČIL Zdeněk MAYER Jiří DVOŘÁKOVÁ Dana

Year of publication 2010
Type Article in Periodical
Magazine / Source Leukemia & Lymphoma
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.3109/10428194.2010.523126
Field Oncology and hematology
Keywords acute myeloid leukemia
Description In conclusion, our data demonstrate that, within the cohort of tested individuals, the IDH2 mutations are associated with AML (in contrast to healthy volunteers), suggesting a role for these mutations in disease pathogenesis. In addition, we show an association of the observed IDH2 mutations with disease status, indicating their potential for MRD monitoring. This report thus indicates that IDH2 p.R140 variants are possible markers for MRD detection. However, an extended investigation of IDH2 mutations kinetics, involving long-term followup and a larger cohort of IDH2 mutated AMLs, will be required to confirm these findings.

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