Publication details

Successful treatment of life-threatening Candida peritonitis in a child with abdominal non-Hodgkin lymphoma using Efungumab and amphotericin B colloid dispersion.

Authors

KŘENOVÁ Zdenka PAVELKA Zdeněk LOKAJ Petr SKOTÁKOVÁ Jarmila KOCMANOVÁ Iva TEYSCHL Otakar KŘEN Leoš MÚDRY Peter ŠTĚRBA Jaroslav

Year of publication 2010
Type Article in Periodical
Magazine / Source Journal of Pediatric Hematology and Oncology
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords Candica peritonitis Efungumab amphotericin B colloid dispersion
Description Invasive fungal infections are serious complications of cancer therapy. We present a case report of a 12-year-old boy diagnosed with abdominal non-Hodgkin lymphoma and fecal and Candida peritonitis during induction chemotherapy. The invasive mycosis was managed using a combined approach of systemic antifungal agents including efungumab and surgical interventions. Efungumab, a recombinant antibody that inhibits extracellular heat shock protein 90, was used in combination with amphotericin B colloid dispersion after the failure of standard approaches.