Publication details

Galactomannan detection in bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in patients with hematological deseases-the role of factors affecting assay performance

Authors

RÁČIL Zdeněk KOCMANOVÁ Iva TOŠKOVÁ Martina BUREŠOVÁ Lucie WEINBERGEROVÁ Barbora LENGEROVÁ Martina ROLENCOVÁ Monika WINTEROVÁ Jana HRNČÍŘOVÁ Kristýna VOLFOVÁ Pavlína SKŘIČKOVÁ Jana MAYER Jiří

Year of publication 2011
Type Article in Periodical
Magazine / Source International Journal of Infectious Diseases
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1016/j.ijid.2011.09.011
Field Oncology and hematology
Keywords galaktomanan; BAL; invazivní plicní aspergilóza; hematologická malignita
Description We evaluated the performance of a galactomannan (GM) assay in bronchoalveolar lavage (BAL) fluid compared to serum samples for the diagnosis of invasive pulmonary aspergillosis (IPA) in patients with hematological diseases. Results: Twenty-eight cases of IPA (11%) were diagnosed. The highest sensitivity (78.6%) with good specificity (98.6%) was obtained with a triple detection of GM in bronchial, alveolar, and serum samples. Neutropenia and antifungal therapy for only 24 h increased the sensitivity, while antifungal treatment for more than 2 days decreased assay performance.Conclusions: In contrast to recently published data, we found only moderate sensitivity, but high specificity and high positive predictive value of the detection of GM in BAL fluid.

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