Publication details

Lung cancer risk attributable to occupational exposures in a multicenter case-control study in Central and Eastern Europe

Authors	OLSSON A. C. GUSTAVSSON P. ZARIDZE D. MUKERIYA A. SZESZENIA-DABROWSKA N. RUDNAI P. LISSOWSKA J. FABIANOVA E. MATES D. BENCKO V. FORETOVÁ Lenka JANOUT V. FEVOTTE J. T MANNETJE A. FLETCHER T. BRENNAN P. BOFFETTA P.
Year of publication	2011
Type	Article in Periodical
Magazine / Source	Journal of occupational and environmental medicine
MU Faculty or unit	Faculty of Medicine
Citation
Doi	http://dx.doi.org/10.1097/JOM.0b013e318234e2d2
Field	Oncology and hematology
Keywords	HUMAN CARCINOGENS; SMOKING; ASBESTOS; MORTALITY; PROPORTION; PREVENTION; STOCKHOLM; RADIATION; WORKERS; BURDEN
Description	To estimate the lung cancer risk attributable to occupational lung carcinogens. Methods: Information was collected through interviews from 2624 newly diagnosed lung cancer cases and 2690 frequency-matched controls in Central and Eastern Europe. Industrial hygiene experts evaluated exposure to 70 occupational agents. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression and attributable fractions (AF) by Miettinen's formula. Results: Exposure to at least one occupational lung carcinogen resulted in an AF of 7.9% in men and 1.4% in women. Metals and silica contributed the most to the AF. The AF was highest for squamous cell carcinoma among men (11.4%) and for small cell carcinoma among women (7.1%); the effect of occupational lung carcinogens was stronger overall among current smokers. Conclusion: This estimation of the AF of occupational lung carcinogens is comparable to that estimated in other European studies, and cannot alone explain the high lung cancer rates in Central and Eastern Europe.