Publication details

Vliv novorozenecké žloutenky na vznik autizmu

Title in English An association between neonatal jaundice and autism


Year of publication 2012
Type Article in Periodical
Magazine / Source Česká a Slovenská Neurologie a Neurochirurgie
MU Faculty or unit

Faculty of Medicine

Field Paediatry
Keywords autism; pathological neonatal jaundice; physiological neonatal jaundice; hyperbilirubinemia
Description Autistic Spectrum Disorders (ASD) include neurodevelopmental disorders characterized by impaired social interaction, communication and stereotyped patterns of behaviour and interests. The aetiology of autism is not fully understood, although both genetic and non-genetic factors are believed to be involved. Pathological neonatal jaundice (PNI) has been considered as a potential cause. Aim of study: The main aim of this study was to determine an association between PNI and autism in full-term and preterm infants. Material and methods: A retrospective case-control study was performed at the Department of Paediatric Neurology and Department of Paediatric Internal Medicine in Brno. The subjects were 328 patients, who had been diagnosed with ASD between 1999 and 2011. Medical records of 402 gender- and age-matched controls without the diagnosis of autism who were examined at the Department of Paediatric Internal Medicine, were also reviewed. Results: The autistic group had noticeable PNI in 17.1% (49/287) full-term infants and 29.3% (12/41) preterm infants. The control group had PNI in 9.5% (35/367) full-term infants and 45.7% (16/35) preterm infants. There was a statistically significant association between neonatal jaundice and autism in full-term infants (OR = 1.95, 95% Cl 1.23-3.10, p = 0.005). The association between neonatal jaundice and autism in preterm infants was not confirmed (OR = 0.49; 95% Cl 0.25-1.33; p = 0.255). Conclusion: The study is the first to describe the association between PNI and autism in the Czech Republic and further studies will be necessary to confirm the results.

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