Informace o projektu

At the Cross-road of Magnetic Fields and Light: A New Perspective of Cell Clock Control.

Kód projektu
MUNI/G/1391/2018
Období řešení
3/2019 - 12/2021
Investor / Programový rámec / typ projektu
Masarykova univerzita
Fakulta / Pracoviště MU
Přírodovědecká fakulta
Další fakulta/pracoviště MU
Lékařská fakulta
Další fakulta/pracoviště MU
Středoevropský technologický institut

It has been clearly shown that there is an association between the circadian clock and human health. A circadian feedback loop of clock gene expression is synchronized by light and the clock protein Cryptochrome (Cry) was shown to mediate such clock entrainment by light in Drosophila. Interestingly, the same protein was shown to be indispensable for magnetoreception and circadian rhythms are impacted by magnetic fields likely via Cry. Despite extensive research, synthetic theoretical framework putting together rather fragmental cases of magnetosensitivity based on Cry is missing, in particular in mammalian cells and tissues. The project addresses still unknown interplay between light and magnetic field on the cellular level under strictly controlled conditions. It gathers three, so far not collaborating, teams to employ state-of-the-art techniques of molecular embryology, genetic analysis and physical treatments to answer several hypotheses all focusing on Cry and other clock genes in the center. We will tackle the problem of mammalian Cry photo- and magnetosensitivity and consequent hypothetical impacts of light and magnetic fields on cellular and developmental programs controlled by circadian clock. The project profits from sharing of theoretical and methodological knowledge as well as unique instrumentation unattainable elsewhere. Due to the novel multidisciplinary approach the outputs may advance our understanding of important environmental impacts on processes orchestrating networks of cellular communication on the intersection of neural function, development, regeneration and circadian control.

Publikace

Počet publikací: 2