iNEXT-Discovery: Infrastructure for transnational access and discovery in integrated structural biology (iNEXT- Discovery)
iNEXT-Discovery, a novel infrastructure for NMR, Electron microscopy (EM) and X-rays for Translational research (iNEXT) will enable the Discovery of new pharmaceuticals, biologics, materials, biofuels, food formulations, and other tools that European scientists can envisage, and that we can help to bring to reality. The iNEXT-Discovery builds on the success of iNEXT, taking it further by enabling more efficient and new cutting-edge structural biology access to users, facilitating for instance fragment-based drug discovery campaigns, the structure determination of large molecular machines, the observation of molecular structures and dynamics within cells, and numerous more applications by the wider user community. iNEXT-Discovery aims to fully release the enormous potential of advanced instruments and top-notch scientific expertise from leading European research infrastructures for structural biology, making it available across scientific disciplines and all across Europe. This main objective will be realised by the coordinated offering of access to the existing structural biology community, but crucially also to user communities that have been less exposed to these facilities. The rich and energetic research environment that is available at all partner sites catalyses the four joint research activities within the iNEXT-Discovery project. We aim to further consolidate a strong structural biology presence in drug discovery pipelines by streamlining fragment based drug discovery pipelines, by high-throughput delivery of samples to maximise the efficiency of user access in our facilities, on offering novel scientific opportunities for following molecules in time, and on developing more efficient tools and procedures to analyse structures in situ within cells. All the iNEXT-Discovery JRAs aim to improve structural biology technology. Also, we will embrace a strong focus on the digitalisation and automation of structural biology services. Together, our JRAs will strongly improve the access provision of the offered technologies to facility users, both novice and experienced.
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