Informace o projektu

Biologically Active Organic Compounds Interacting with Adenine-binding Proteins (bioactivecpds)

Kód projektu
230936
Období řešení
1/2010 - 4/2015
Investor/Program
Evropská unie
Programový rámec / typ projektu
7. rámcový program EU - Lidé
Fakulta/Pracoviště MU
Přírodovědecká fakulta

Proposed are rational design and synthesis of novel patentable organic compounds that are envisioned to be active against various adenine-binding proteins, e.g. kinases. The structures contain heterocyclic cores relatively unknown in the literature and will mimic interactions of purine-containing biological substrates (especially ATP) with proteins that are relevant in oncology. The compounds will be synthesized by modern methods of organic synthesis, namely by ring-closing metathesis and will be profiled in biological asssays that include diverse biological targets, especially those that are relevant to the treatment of cancer.

Publikace

2015

Substituované furo[3,2-b]pyridiny pro použití jako léčiva

PARUCH KamilPETRŮJOVÁ Michaela

2013

Quantum Mechanical Scoring: Structural and Energetic Insights into Cyclin-Dependent Kinase 2 Inhibition by Pyrazolo[1,5-a]pyrimidines

BRAHMKSHATRIYA Pathik S. — DOBEŠ Petr — FANFRLÍK Jindřich — ŘEZÁČ Jan — PARUCH Kamil — BRONOWSKA Agnieszka — LEPŠÍK Martin — HOBZA Pavel

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