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Characteristics of Staphylococcus aureus strains resistant to polyvalent bacteriophages used for phage therapy

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DOŠKAŘ Jiří ŠTREITOVÁ Markéta FORMANOVÁ Petra VARGA Marian PANTŮČEK Roman

Rok publikování 2013
Druh Konferenční abstrakty
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
Popis The polyvalent staphylococcal bacteriophage phi812 and its host-range mutants, members of Myoviridae family, lyse most of Staphylococcus aureus strains and are, therefore, used in therapy of staphylococcal infections. However, some 5-10% of the strains are insensitive to these phages, which may reduce the effectiveness of phage-based therapy. In this work we analysed the possible defence mechanisms of the strains which can result in their insensitivity to phages. Therefore, we examined correlation between strain insensitivity and efficiency of phage adsorption on bacterial cells, presence of the SauI restriction-modification (RM) system and content of resident prophages. For the study, a set of genotypically well characterized S. aureus strains from distinct clonal complexes (CC) differing in their prophage content was used.
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