Informace o publikaci

Human Pluripotent Stem Cell-Derived Cardiomyocytes as Research and Therapeutic Tools

Autoři

AĆIMOVIĆ Ivana VILOTIĆ Aleksandra PEŠL Martin LACAMPAGNE Alain DVOŘÁK Petr ROTREKL Vladimír MELI Albano

Druh Článek v odborném periodiku
Časopis / Zdroj BioMed Research International
Fakulta / Pracoviště MU

Lékařská fakulta Rektorát

Citace
WWW http://downloads.hindawi.com/journals/bmri/2014/512831.pdf
Doi http://dx.doi.org/10.1155/2014/512831
Obor Genetika a molekulární biologie
Klíčová slova human pluripotent stem cell; differentiation; cardiomyocyte; calcium; disease model
Popis Human pluripotent stem cells (hPSCs), namely, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), with their ability of indefinite self-renewal and capability to differentiate into cell types derivatives of all three germlayers, represent a powerful research tool in developmental biology, for drug screening, disease modelling, and potentially cell replacement therapy. Efficient differentiation protocols that would result in the cell type of our interest are needed for maximal exploitation of these cells. In the present work, we aim at focusing on the protocols for differentiation of hPSCs into functional cardiomyocytes in vitro as well as achievements in the heart disease modelling and drug testing on the patient-specific iPSC-derived cardiomyocytes (iPSC-CMs).
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info