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The role of c-Myb in survival signaling pathways of colorectal carcinoma cells

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PEKARČÍKOVÁ Lucie KNOPFOVÁ Lucia ŠMARDA Jan

Rok publikování 2014
Druh Konferenční abstrakty
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
Popis Colorectal carcinoma (CRC) is the third most common cancer in the world and is one of the leading causes of cancer-related deaths. The c-Myb is transcription factor playing essential role in control of proliferation, differentiation and apoptosis of epithelial cells. c-Myb overexpression in CRC is known to be a prognostic indicator for poor survival of patients. The aim of this study was to clarify the role of c-Myb in control of death/survival of CRC cells. We showed that the c-Myb protein reduced sensitivity of these cells to the cytostatic agens. We found that fraction of CRC cells with depolarized mitochondrial membrane decreases upon expression of c-Myb. Mitochondria are a major site of production of reactive oxygen species that play important role in regulation of cell survival. We tested the level of reactive oxygen species and expression/activity of key components of several signaling pathways in c-Myb-expressing cells to identify the downstream effectors mediating the effects of c-Myb on cell viability. In this work, we describe a novel c-Myb-p38?/JNK signal axis mediating increased resistance of colorectal cells to cytotoxic agents and discuss the role of reactive oxygen species in these signaling pathways.
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