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The Enhancement of Electrochemical Sensing of Guanine Derivatives by Using PVP Capped Copper Nanoparticles

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Rok publikování 2014
Druh Konferenční abstrakty
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Popis Purine derivatives play an important role in the regulation of biological functions and understanding their redox behavior is a primary task for electrochemical methods. The aim of the contribution is to present a new electrochemical analysis which suggests an efficient way for a sensitive and selective determination of purine analytes including compounds. the increase of sensitivity and selectivity in oxidation rsponses of guanine and its derivatives (methyl-, thio-) was achieved by using a chemical modification of graphite (pencil, screen printed) electrodes. The first modification of the graphite electrode was carried out by monovalent copper ions which were generated in situ on the electrode surface; then cuprous ions with guanine derivatives are able to form sparingly soluble complexes strongly adsorbed on the electrode surface, resulting in a significant enhancement of oxidation signals. The second modification of a graphite electrode consists in the application of metallic (Cu or CuAg) nanoparticles (NPs) which posses great potential application in the field of photovoltaics, chemical sensing and biosensors. The metallic or bimetallic NPs used were stabilized by the polypyrrolidone (PVP) shell. To evaluate the effect of NPs on oxidation processes of guanine derivatives we determined the size and zeta potential f NPs by using a zetasizer. In addition, the graphite electrode surfaces were characterized by a scanning electron microscope (SEM). It was found that graphite electrodes modified by metallic Cu NPs provide the best results. A possible explanation can be accepted: while monometalic Cu NPs forms Cu(I)-guanine complexes the bimetallic CuAg NPs is not able to do so.
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