Informace o publikaci

Microarray analysis of mandible regionalization during mouse development

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Rok publikování 2015
Druh Konferenční abstrakty
Fakulta / Pracoviště MU

Lékařská fakulta

Popis The mammalian teeth function to capture and chew food and they have become specialized for these purposes producing a complex and distinctive dentition consisting of unicuspid and multicuspid teeth. To achieve this specialization, tooth development is characterized by a complex series of reciprocal interactions that occur between the epithelium and the underlying cranial neural crest-derived mesenchyme that regulates tooth morphogenesis and differentiation at molecular level. Up to now several homeobox genes are known to be expressed in specific pattern of mouse mandible that specifies the incisor and molar area. However, there are still many unsolved questions how complex signaling between the epithelium and mesenchyme is regulated during initial development of different classes of teeth. To reveal these complex molecular bases of tooth development, a polygenetic approach is needed. Here, we aim to uncover signaling cascades between the oral epithelium and mesenchyme along the jaw that underlay heterodont dentition in mammals.
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