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Long-term Survival with Ipilimumab: Experience from a National Expanded Access Program for Patients with Melanoma

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KRAJSOVÁ Ivana ARENBERGER Petr LAKOMÝ Radek KUBALA Eugen BŘEZINOVÁ Ivana POPRACH Alexandr ŠŤASTNÝ Marek MUŽÍK Jan MELICHAR Bohuslav

Rok publikování 2015
Druh Článek v odborném periodiku
Časopis / Zdroj Anticancer Research
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Onkologie a hematologie
Klíčová slova Melanoma; ipilimumab; survival; safety
Popis Aim: Evaluation of efficacy and safety of ipilimumab in patients with advanced, refractory melanoma enrolled into a national ipilimumab Expanded Access Program. Patients and Methods: Adult patients with advanced/metastatic refractory melanoma were eligible for study inclusion. Ipilimumab was administered up to a total of four doses. Results: One hundred and ninety-six patients were analyzed. Full ipilimumab induction was administered to 66.8% of patients. Median overall survival (OS) in the entire cohort was 7.5 months. Median OS for patients after four doses of ipilimumab was significantly longer than for patients with fewer doses (12.3 months vs. 2.0 months respectively; p<0.001). Median OS for patients with objective tumor response was 42.3 months. Normal baseline serum lactate dehydrogenase (LDH) and C-reactive protein (CRP) levels, and the number of affected organs correlated with improved OS. Conclusion: The number of affected organs and combination of baseline LDH and CRP levels could potentially serve as predictors for both treatment response and OS.

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