Informace o publikaci
Determination of interactions of human serum albumin and its glycated form with antidiabetic drugs by CE-FA
| Název česky | Stanovení interakcí lidského sérového albuminu a jeho glykované formy s antidiabetiky pomocí metody CE-FA |
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| Autoři | |
| Rok publikování | 2016 |
| Druh | Článek ve sborníku |
| Konference | Advances in chromatography and electrophoresis, Chiranal 2016 |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Biochemie |
| Klíčová slova | binding constant, capillary electrophoresis - frontal analysis, antidiabetic drugs, HSA |
| Přiložené soubory | |
| Popis | The binding constants (Kb) of systems HSA or glycated HSA (gHSA) with antidaibetic drugs were determined by capillary electrophoresis – frontal analysis (CE-FA). Apparent Kb values were obtained by nonlinear regression analysis. The Kb of HSA-drug and gHSA-drug were compared. The Kb values of glycated form were lower than nonglycated albumin. This modification influences strenght of binding between gHSA and antibiabetc drugs. |
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