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Prolonged QT Interval in Neurodevelopmental Rat Model of Schizophrenia

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STRAČINA Tibor RONZHINA Marina ŠTARK Tibor RUDÁ Jana OLŠANSKÁ Eva VESELÝ Petr MICALE Vincenzo NOVÁKOVÁ Marie

Rok publikování 2017
Druh Článek ve sborníku
Konference Computing in Cardiology 2016
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://ieeexplore.ieee.org/document/7868926/
Obor Fyziologie
Klíčová slova QT prolongation
Přiložené soubory
Popis QT prolongation is an independent risk factor for development of ventricular arrhythmias and eventually sudden cardiac death. It is common side effect of various medications, including antipsychotics. It was reported that schizophrenic patients treated with antipsychotics (e.g. haloperidol, olanzapine) manifested QT prolongation. Also, drug-free schizophrenic patients have increased QT interval compared to healthy controls. Possible mechanisms of QT prolongation connected with schizophrenia are still unclear. The present study on isolated hearts clearly shows that rats with schizophrenia-like phenotype manifest significantly lengthened QT interval as compared to controls. This difference was further increased after acute haloperidol administration. These data indicate that methylazoxymethanol acetate rat model of schizophrenia may be applicable tool for studying of connection between schizophrenia and QT prolongation.
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