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Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease

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RAUDENSKÁ Martina DVOŘÁKOVÁ Veronika PÁCAL Lukáš CHALÁSOVÁ Katarína KRATOCHVÍLOVÁ Monika GUMULEC Jaromír RUTTKAY-NEDECKY B. ZITKA O. KAŇKOVÁ Kateřina ADAM V. MASAŘÍK Michal

Rok publikování 2017
Druh Článek v odborném periodiku
Časopis / Zdroj JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1002/jbt.21891
Obor Biochemie
Klíčová slova diabetes; diabetic kidney disease; heavy metals; metallothionein; oxidative stress
Popis Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT), metals (zinc and copper), and selected antioxidants (bilirubin, cysteine, and glutathione) were determined in 70 type 2 diabetes mellitus (T2DM) subjects and 80 healthy subjects of Caucasian origin. Single nucleotide polymorphism (rs28366003) in MT gene was detected. Antiradical capacity, conjugated bilirubin, and copper were significantly increased in diabetics, whereas MT and glutathione were decreased. Genotype AA of rs28366003 was associated with higher zinc levels in the diabetic group. The studied parameters were not influenced by renal function. This is the first study comprehensively investigating differences in MT and metals relevant to oxidative stress in T2DM. Ascertained differences indicate increased oxidative stress in T2DM accompanied by abnormalities in non-enzymatic antioxidant defense systems.
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